Mitsunobu reaction | ChemFinder

Mitsunobu reaction

Reaction scheme

Reaction mechanism

alcohol, amide, DEAD, diol, ester, ether, nucleophile attack, ring closure, SN2

February 24, 2011

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acyl azide alcohol aldehyde alkene amide amine aromatic azide bicycle boronic acid carbonyl coupling reaction cross-coupling cyclization DEAD dimere diol EAS electrophile aromatic substitution enyne ester ether five-membered Formylation haloketone heterocycle hydrazide imine Indole isocyanate ketone Mannich nucleophile attack oxazaborolidine Pd intermediated phenylhydrazine rearrangement reduction ring closure SN2 stereospecific Suzuki coupling triazole zirconium